SOD2 and Fabry disease: Consequently,, researchers have begun to explore the novel mechanisms of tissue damage caused by FD, leading to the discovery of α-synuclein, mitochondrial mechanism, the Sod2 pathway and other mechanisms that contribute to cell damage, thereby revealing the causes of end-organ damage induced by FD.Additionally, the emergence of adjunctive therapy drugs also addresses the issue that existing drugs cannot improve damaged cells and tissues.