In addition, a decrease in Sod2 activity was also observed, and a similar change in Sod2 activity was observed in a study of human FD patients [44]; however, it was proposed that the decrease in Sod2 activity was not related to Gb3 accumulation, suggesting that the change in Sod2 activity is a new pathway independent of Gb3. The gene discussed is SOD2; the disease is Fabry disease.