To further confirm that WBP1 depletion induces ferroptosis, we treated WBP1 KO cells with ferrostatin-1 (Fer-1), a specific inhibitor of ferroptosis (Ma et al. 2022; Scarpellini et al. 2023; Miotto et al. 2020) and observed that Fer-1 treatment significantly rescued the impaired cell proliferation in WBP1 KO CRC cells (Fig. 2C and D). This evidence concerns the gene WBP1 and colorectal carcinoma.