A ramipril therapy that mainly targets the renin‒angiotensin‒aldosterone system (RAAS) to ameliorate AS-related kidney arterial hypertension effectively reduces TGFβ levels and thereby inhibits renal fibrosis (Gross et al. 2003), suggesting an important role of TGFβ in renal fibrosis. The gene discussed is REN; the disease is renal fibrosis.