Moreover, genes associated with IL-6 and TNF response, as well as chloride transmembrane transport, showed to be enriched in AS compared to NS, consistent with reported immune/inflammatory responses and sweating alterations in CRPS (Harden et al. 2010; Birklein et al. 2014; Üçeyler et al. 2007; Alexander et al. 2012). This evidence concerns the gene IL6 and complex regional pain syndrome.