We found that activin co-localization was associated with an increase in Phospho-Tuberin in both the tumoral (2.95 ± 0.67 normalized counts) and stromal (1.48 ± 0.47 normalized counts) compartments of stage III tissue samples when compared to activin (-) AOIs (tumor: 0.52 ± 0.17 normalized counts; stroma: 0.55 ± 0.14 normalized counts) (Fig. 3A). This evidence concerns the gene INHBE and neoplasm.