Similarly, Phospho-PRAS40 expression was increased in stage III CRC tissue samples in activin (+) AOIs of the tumoral (4.65 ± 1.89 normalized counts) and stromal (2.60 ± 1.17 normalized counts) compartments when compared to activin (-) AOIs (tumor: 0.48 ± 0.18 normalized counts; stroma: 0.52 ± 0.11 normalized counts) (Fig. 3B). This evidence concerns the gene AKT1S1 and neoplasm.