According to the KEGG annotation database, several pathways associated with innate immunity, including Salmonella infection, the C-type lectin receptor signaling pathway, HSV1 infection, the cytosolic DNA sensing pathway, the RIG-I-like receptor signaling pathway and the Toll-like receptor signaling pathway, were significantly impaired (Fig. 5B). This evidence concerns the gene CLEC4D and Salmonella Infections.