NOTCH3 and Ehlers-Danlos syndrome: Other disorders associated with the development of congenital vascular diseases include cerebral autosomal-dominant arteriopathy with subcortical infarcts and lymphedema distichiasis syndrome (LDS; characterized by FOXC2 gene mutations), leukoencephalopathy (characterized by Notch3 gene mutations), Ehlers-Danlos syndrome (EDS; which is a severe congenital neutropenia characterized by changes in the G6PC3) and Chuvash Polycythemia (characterized by VHL mutations) (Fukaya et al. 2018).