Although ADM was initially isolated from human adrenal tumours, recent studies have demonstrated that ADM mRNA is overexpressed in multiple tumour tissues and promoting angiogenesis and tumour growth, and its expression is closely associated with the histological grading of various tumours via regulating the production of vascular endothelial growth factor (VEGF) [12, 13]. Here, VEGFA is linked to adrenal gland neoplasm.