IL4R and Alzheimer disease: Dupilumab, a fully human Ig4 monoclonal antibody directed against the Interleukin-4 Receptor subunit alpha (IL-4Rα) of IL-4 and IL-13 receptors, is a biologic therapy that has revolutionized the treatment of AD, with landmark trials demonstrating its efficacy in significantly reducing pruritus.12, 13 Janus Kinase (JAK) inhibitors have also been increasingly used in patients with AD.