LIMK2 and Alzheimer disease: They all showed risk influence on AD (LIMK2 OR 1.084 (1.019–1.154), MAPK8 OR 0.943 (0.899–0.989), and NDUFV2 OR 0.943 (0.904–0.983)) in brain tissues (Fig. 8A), and (LIMK2 OR 1.097 (1.019–1.181), MAPK8 OR 0.837 (0.731–0.960), and NDUFV2 OR 0.938 (0.891–0.987)) in blood samples (Fig. 8B).