They all showed risk influence on AD (LIMK2 OR 1.084 (1.019–1.154), MAPK8 OR 0.943 (0.899–0.989), and NDUFV2 OR 0.943 (0.904–0.983)) in brain tissues (Fig. 8A), and (LIMK2 OR 1.097 (1.019–1.181), MAPK8 OR 0.837 (0.731–0.960), and NDUFV2 OR 0.938 (0.891–0.987)) in blood samples (Fig. 8B). The gene discussed is MAPK8; the disease is Alzheimer disease.