Our analysis identified twelve pivotal hub genes ETNK1, BICRA, IL-1R1, KDM3A, ARID2, GSK3β, EZH2, NOTCH1, SMARCA4, FOS, CREB1, and CASP3 that play significant roles in driving the molecular dynamics of HCC. The gene discussed is CREB1; the disease is hepatocellular carcinoma.