FASN and obesity due to melanocortin 4 receptor deficiency: In addition, acetyl-CoA carboxylase (ACC) phosphorylation significantly decreased whereas fatty acid synthase (FASN) levels and triacylglycerol content significantly increased in the livers of rats fed SPs compared with rats fed CPs [15], indicating that the absorbable food texture of the SPs did not induce obesity but induced a rat equivalent of T2D (rT2D).