KCNJ10 and EAST syndrome: They play critical roles in regulation of local and whole-body potassium levels, and hence, electrolyte homeostasis (1), and Kir4.1 loss-of-function mutations cause Seizures, Sensorineural deafness, Ataxia, intellectual (Mental) disability, and Electrolyte imbalance (SeSAME) syndrome (6), also known as EAST syndrome (7).