TARDBP and multiple system atrophy: Our analysis of the entire longitudinal dataset revealed varying frequencies of co-pathologies, including DLB (15.45%), TDP-43 (3.79%), Parkinson's disease (PD) (6.78%), Lewy body spectrum (LBS) (25.75%), progressive supranuclear palsy (PSP) (2.44%), vascular dementia (VaD) (9.76%), multiple system atrophy (MSA) (0.27%), and AD-only/alone (34.96%) (Fig. 1B).