Fasting alters reward-related behaviors and decreases baseline DA levels.16Also, several innate immune cytokines such as IFN-α is reported to produce high rates of behavioral disturbances, including depression and fatigue.17DA is involved in multiple behaviors, including feeding, and chronic fasting is known to affect DA neural circuits significantly due to a reduction in food intake and associated body weight. The gene discussed is IFNA2; the disease is depressive symptom measurement.