Fasting alters reward-related behaviors and decreases baseline DA levels.16Also, several innate immune cytokines such as IFN-α is reported to produce high rates of behavioral disturbances, including depression and fatigue.17DA is involved in multiple behaviors, including feeding, and chronic fasting is known to affect DA neural circuits significantly due to a reduction in food intake and associated body weight. This evidence concerns the gene IFNA1 and major depressive disorder.