Similarly, for bowel cancer (MIM: 114500), GWASs have identified over 200 common susceptibility loci,6 and rare variants have been identified in mismatch repair (MMR) genes including MSH2 (MIM: 609309), MSH6 (MIM: 600678), MLH1 (MIM: 120436), and PMS2 (MIM: 600259), as well other genes including APC7 (MIM: 611731). This evidence concerns the gene MSH2 and intestinal cancer.