A marked induction of apoptosis as shown by positivity for Annexin-V and 7-AAD following 24 h exposure to 2.5 and 5 μM CM14 was seen in all 4 ALCL cell lines tested, whereas only minor effects were observed for CAPE (Fig. 2C–SFig. 1A). Here, SMC2 is linked to anaplastic large cell lymphoma.