Ingenuity pathway analysis of male VICs with UTY-KD on blank (Fig. 6C) and PS-NP gels (Fig. 6D) showed strong associations to pathways related to osteoblasts and chondrocytes in inflammatory diseases, osteoarthritis signaling, and interleukin-4, interleukin-13, and interleukin-17 signaling, among others. This evidence concerns the gene IL4 and osteoarthritis.