NPY and pachyonychia congenita: To determine whether NPY expression was also up-regulated in tumors of human patients with PC, and to assess the clinical relevance of targeting NPY, we next interrogated the publicly available The Cancer Genomic Atlas (TCGA) dataset via OncoDB (60) and found that NPY mRNA expression was significantly elevated in PDAC tumors relative to the normal pancreas (Fig. 1G).