Given that Npy/NPY and Npy1r expression is up-regulated in the highly metastatic KPR172HC mouse model and NPY1R was the most highly expressed receptor in human PDAC, we next wanted to investigate the effect of genetic ablation of Npy1r on disease progression in the genetically engineered KPR172HC mouse model of PC. Here, NPY is linked to pachyonychia congenita.