Down-regulated transcripts and proteins included genes previously described to be regulated by NPY (70), such as CCN2, whose inhibition has been shown to decrease bone metastases of MDA-MB-231 breast cancer cells (71), as well as CIRBP, which was previously found to be required for metastasis in a xenograft mouse model of bladder cancer (72). The gene discussed is CCN2; the disease is breast cancer.