Therefore, we initially assessed the expression of NPY ligands and their receptors in two autochthonous, genetically engineered mouse models (GEMMs) of PC: the low metastatic KPfloxC model (Pdx1-Cre; LSL-KrasG12D/+; Trp53flox/+; Fig. 1A) (16, 58) and the highly metastatic KPR172HC model (Pdx1-Cre; LSL-KrasG12D/+; LSL-Trp53R172H/+; Fig. 1A) (11, 16, 58). Here, NPY is linked to pachyonychia congenita.