SPIC and bacterial infectious disease with sepsis: Spic−/− mice showed a similar extent of severe functional deficiency as high CL-treated and SPX mice in clearing HV pneumococci, with sustained bacteremia in the first 12 hours post intravenous inoculation of Spn6A, whereas Nr1h3−/− mice displayed a virtually normal pattern of bacterial clearance as wild-type (WT) control (Fig. 2B).