CALCA and infection: In line with the importance of liver-resident macrophages in eliminating LV pneumococci (17), KC-deficient mice (Clec4f-DTR mice treated with diphtheria toxin, +DT) showed remarkable deficiency in removing Spn14 in the first 12 hours post intravenous infection as compared with the untreated mice (−DT) (Fig. 8F).