However, the role of these yeast species in producing other virulence factors like secreted aspartic proteinase (SAP) need to be better explored in future studies being that these enzymes are able to cause both mechanical damages (i.e., deteriorate epithelial and mucosal barrier proteins such as collagen, keratin and mucin) and immunological escape (complement, cytokines and immunoglobulins degradation) during the infection process [34]. The gene discussed is MUC5AC; the disease is infection.