With regard to polyester-polymer alloy dialyzers, they should be used in young patients who need the boosting of dialysis purification due to erythropoietin stimulating agent resistance or an inflammatory state, in patients with diabetes undergoing insulin therapy [22], and in patients affected by acute kidney injury (AKI) due to multiple myeloma to remove free light chains with the use of two filters during each 4-h HD session [16]. The gene discussed is INS; the disease is acute kidney injury.