CD4 and glaucoma: While this study establishes the involvement of CD4+ T cells in glaucoma progression, it also highlights the need for further research to elucidate the specific role of the Th17 response in this context, given that Th17 cells, which are also primed by commensal microflora, have been previously demonstrated to be essential in the development of the spontaneous R161H model of EAU [34].