Our study determined the causalities between inflammatory cytokines, blood metabolites, and thyroid cancer through MR analysis, identifying a group of inflammatory cytokines and blood metabolites that can cause the thyroid cancer, uncovering the mediating effect of specific blood metabolites between TNFSF14 and thyroid cancer, highlighting the critical roles of inflammatory and metabolic pathways in the pathogenesis of thyroid cancer. The gene discussed is TNFSF14; the disease is thyroid gland carcinoma.