PTGS2 and Alzheimer disease: The neuroprotective effects of IPC-EtOH are attributed to its antioxidant and anti-inflammatory activities, which retard cerebrovascular aging and the emergence of AD as confirmed by immunohistochemical examination that revealed that AD rats treated with IPC-EtOH showed a significant reduction in the inflammatory marker COX-2 immunoexpression, which confirms the IPC-EtOH effective role as an anti-inflammatory agent.