These results are consistent with the previous results of Elkomy et al. (Elkomy et al. 2021), who reported that donepezil treatment of rats protected from AD development because of the administration of AlCl3, improved symptoms of AD significantly and significantly elevated the levels of GSH and SOD, indicating that its antioxidant capacity contributed to its ability to improve the prognosis of AD. This evidence concerns the gene SOD1 and Alzheimer disease.