NFKB1 and psoriasis: Phenolic compounds can also up- or down regulate transcriptional elements involved in antioxidant pathways, such as nuclear factor-κB (NF-κB), these compounds believed to reduce oxidative stress either individually or in combination (Contardi et al. 2021).This reduction, in turn, suppresses inflammatory pathways and suggests a potential therapeutic application for treating psoriasis (Xie et al. 2021).