These two lung NET samples seem to resemble the highly proliferating NET G3 cases of gastroenteropancreatic origin and might relate to the recently recognized entity of “carcinoids with elevated mitotic counts and/or Ki67 proliferation index” [2] or to the discovery of supra-carcinoids (tumors with carcinoid morphology but LC-NEC molecular characteristics) in the methylation study from Alcala et al. [15]. This evidence concerns the gene MKI67 and neuroendocrine carcinoma.