HDAC3 and Cognitive impairment: In addition, scutellarin, a purified flavonoid, modulates amyloid-beta (Aβ) assembly, thereby reversing cognitive impairment and neuroinflammation by regulating the gut microbiota and cAMP/protein kinase A (PKA)/cAMP response element binding protein (CREB)/histone deacetylase 3 (HDAC3) pathways in microglia [25].