Notably, the main inherited risk variant for MASLD/MASH in the PNPLA3 gene underlying this heterogeneity has been associated with increased hepatic secretion of proinflammatory cytokines [59], reduced susceptibility to some skin infections [60] and to severe COVID‐19 [61, 62, 63]. This evidence concerns the gene PNPLA3 and metabolic dysfunction-associated steatotic liver disease.