While in patients and immunohistochemical analyses, the enzymes that presented a higher level of expression in tumor tissue were SLC2A1, HK2, ALDOC, PFKP, TPI1, GAPDH, PGK1, LDHA, SLC1A5, GLS2, and GOT1 (Figure S2B,C). The gene discussed is GLS2; the disease is neoplasm.