Experimental data suggested that DPP-4 inhibition may have direct protective effects on the heart after myocardial infarction by improving cardiac function and decreasing the infarct size; in this context, DPP-4 inhibition induces an antiapoptotic effect, with the involvement of the SDF-1α/CXCR4-mediated STAT3 signaling pathway [70]. This evidence concerns the gene DPP4 and myocardial infarction.