DPP4 and type 2 diabetes mellitus: In addition, some experimental studies suggested a relationship between elevated DPP-4 and an unfavorable lipid profile; in humans, an association between sDPP-4 and triglyceride levels was evidenced, while patients treated for 24 months with a DPP-4is-based combination with metformin exhibited an improved lipid profile, especially for triglycerides and LDL, when compared to baseline in T2D patients [67].