Other data suggested that dapagliflozin improved mitochondrial dynamics optic atrophy 1 (OPA1), DRP1, and MFN2, together with the levels of proteins related to skeletal muscle mitochondrial biogenesis (PGC-1α, NRF1, TFAM, and COX IV) and mitophagy (PGAM5 and PINK1) in T2D rats [123], whereas it induced improvement of fusion–fission proteins mitofusin-1 (Mfn-1,) Mfn-2, and mitochondrial fission 1 (Fis-1) in a rat model of metabolic syndrome [124]. This evidence concerns the gene FIS1 and metabolic syndrome.