Among the 11 growth factor-related proteins—EGF1, EGFR, EGFRvIII, FGF8, FGF9, FGF17, FGFR1, VEGF-D, IGF1, IGF-1sR, and PDGFRA—that showed significant differences between women with PCOS and controls, these changes were found to be independent of BMI, inflammation (indicated by the lack of correlation with CRP), or IR, suggesting that these differences are intrinsic to PCOS itself. This evidence concerns the gene FGF8 and polycystic ovary syndrome.