Our findings show reduced plasma EGF1 and EGFR levels in women with PCOS and, here, plasma EGF was no longer different when BMI was stratified and plasma EGFR was no longer different when BMI and IR were stratified, suggesting that EGF1 is BMI dependent; however, there are no comparable studies looking at serum EGF1 and EGFR in PCOS in the literature, and the effect of BMI on EGF1 and EGFR levels from other studies are discrepant. Here, GFM1 is linked to polycystic ovary syndrome.