Interestingly, a recent study has shown that impaired FGFR1 signaling is associated with IR and metabolic dysfunction, further supporting the relevance of our findings [36]; however, after stratification for both BMI and HOMA-IR, it still differed between the women with and without PCOS suggesting that it is independent of both BMI and IR. Here, FGFR1 is linked to polycystic ovary syndrome.