Recently, Jeon et al. have identified the transglutaminase 2 (TGase2)/AMP-activated protein kinase (AMPK)/ glyceraldehyde 3-phosphate dehydrogenase (GAPDH) pathway as a key molecular mechanism underlying hyperglycemia-induced microvascular leakage in DR [41]. The gene discussed is GAPDH; the disease is Hyperglycemia.