BRCA2 and ovarian carcinoma: It should be noted that most women can develop ovarian cancer without being at high risk; however, several factors may increase their risk of developing the disease during their lifetime, including age (>62 years), family history of ovarian cancer, inherited mutation in the DNA damage repair genes BRCA1 (breast cancer gene 1), and BRCA2 (breast cancer gene 2), genetic mutations associated with Lynch syndrome, use of hormone replacement therapy, history of endometriosis, and reproductive factors [72,73,74,75,76,77].