Although previous studies have demonstrated a reduction in breast cancer cell migration and invasion following treatment with CM from immortalized MSC—an effect partially reversed by TIMP-1 inhibition [38]—the inhibitory activity of TIMP-1 may not be sufficient to counterbalance the heightened MMP activity observed in ASCs, which appears to be higher than in other MSCs sources [39]. The gene discussed is TIMP1; the disease is breast carcinoma.