CRELD2 and metabolic dysfunction-associated steatohepatitis: Since CRELD2 is an ER stress-associated gene that has been proposed as a biomarker for diseases linked to ER stress like NASH, diabetes, kidney disease, CVDs, and cancers, we extended our study to provide the proof of concept for bio-functionally validating the AAV-RNAi tool in a disease model of metabolic syndrome [22,57,58].