Indeed, it has been demonstrated that male mice lacking the C-terminus in the p53 AS isoform are more susceptible to Myc-induced B-cell lymphoma than females because of the low expression of the p53 target ACKR4, which is a chemokine receptor important for modulating cellular proliferation and migration [84]. The gene discussed is TP53; the disease is B-cell non-Hodgkin lymphoma.