The generally increased ameloblast height and the regionally increased F-actin intensity in the apical membrane area observed in Cobl KO mice at the developmental time point P0 may appear counterintuitive considering that the actin nucleator Cobl promotes the formation of actin filaments already at low concentrations [9] and is a positive regulator of dendritogenesis and regrowth of the dendritic tree after stroke [9,13]. This evidence concerns the gene COBL and stroke disorder.