Similarly, Kotyla et al., in a study of 15 SLE aPL carriers prescribed 20 mg of simvastatin a day for 28 days, reported decreased concentrations of IL-6, CRP, CAM, and P-selectin, as well as reduced levels of aCL IgG and β2GP1 IgG titres [135]. This evidence concerns the gene APOH and systemic lupus erythematosus.