Finally, Mazurek et al., in a separate study of 18 patients with SLE (only 2 with high aPL titres), found that 20 mg of simvastatin a day for 28 days resulted in decreased CRP levels only, with no changes in ICAM-1, vWF, or aCL IgG and β2GP1 IgG titres [136]. Here, ICAM1 is linked to systemic lupus erythematosus.