DCX and Parkinson disease: A transgenic rat model of PD that carries a human full-length α-syn sequence, generated by Kohl and co-workers (2016) [65], exhibits severely reduced dendritogenesis and alterations in the expression patterns of various synaptic proteins and markedly lower survival rates of hippocampal DCX+ neuroblasts, preceding the loss of DA neurons and the onset of motor deficits; a possible link has been suggested between these alterations and deficits in the serotonergic input to the hippocampus [65] that have been associated with the early non-motor symptoms of PD, such as anxiety and depression.