Alterations in adult hippocampal neurogenesis have been demonstrated in various animal models of AD, such as the PDAPP mouse model that overexpresses a mutant form of the APP protein and presents the age-dependent accumulation of Aβ plaques [60]; the reduction in SGZ neurogenesis, associated with an abnormal maturation of newly generated neurons, parallels the appearance of behavioral deficits in these animals. The gene discussed is APP; the disease is Alzheimer disease.