By integrating scRNA-seq data, chromatin accessibility data (ATAC-seq), and spatially resolved transcriptomic data from various physiological zones and time points of the myocardium in patients with myocardial infarction and controls, they identified SPP1+ macrophages (SPP1+ CD36+) as a significant cell type that expands in ischemic heart tissues following myocardial infarction (MI; cf. Table 1, Figure 1). The gene discussed is SPP1; the disease is myocardial infarction.