HAVCR2 and central nervous system cancer: Several studies, including our recent work [35], have demonstrated that the global expression of TIM-3 (or the HAVCR2 gene that encodes for TIM-3) correlates with the survival of glioblastoma patients, and that HAVCR2/TIM-3 expression is significantly increased in glioblastoma compared to lower grade glioma and brain tissue that does not contain tumor [66,67,68,69,70,71,72,73,74,75].