Another recent article, however, showed that the human anti-TIM-3 antibody (BMS-986258) could not significantly extend the survival of mice bearing CT-2A mouse glioma cells, but could significantly enhanced the survival of mice bearing diffuse intrinsic pontine glioma (DIPG) cells intracranially [125]. Here, HAVCR2 is linked to diffuse intrinsic pontine glioma.