CD4 and neoplasm: In addition, Han and colleagues showed that the percentage of TIM-3 positivity on peripheral CD8+ T cells (but not CD4+ T cells) inversely correlated with Karnofsky scores [68], while Liu et al. showed that the percentage of TIM-3 positivity on both tumor-infiltrating CD4+ and CD8+ T cells correlated with Karnofsky scores [71].