PTTG1 enhances EMT by upregulating transcription factors such as Snail and Twist via TGF-β signaling, suppressing E-cadherin, and promoting invasiveness and metastasis while also modulating NF-κB signaling and tumor cell survival, particularly in aggressive cancers like glioblastoma and HCC. The gene discussed is PTTG1; the disease is hepatocellular carcinoma.