DSG2 and chronic obstructive pulmonary disease: Studies employing a transgenic mutant DSG2 mouse model, in which wild-type DSG2 alleles were replaced by mutant alleles coding DSG2 lacking parts of adhesive domains, exhibited a series of abnormalities, including dissociation of IDs and inflammation, and eventual ARVC with ventricular dilation, fibrosis, and cardiac arrhythmia [485].