GLA and Fabry disease: Fabry disease (FD) is an inherited X-linked disorder characterized by a deficiency of the lysosomal enzyme α-galactosidase A (α–Gal A) (EC entry 3.2.1.22) due to mutations in the GLA gene (Gene Entrez: 2717; NCBI reference: NM_000169.3; OMIM #3006440).