PCA was used to identify underlying dimensions of inflammatory and growth factor activity from 18 biomarkers measured in 45 FD patients and included the following parameters: age, FGF2, NF-kB, Il-6, TNF-α, TNFR2, MCP-1 (CCL2), INF-γ, VEGF, GM-CSF, PIGF, TGF-β, active TGF-β, IGF-1, IL-10, Il-2, IL-1α, and IL-1β. The gene discussed is TNF; the disease is Fabry disease.