By expressing tumor necrosis factor superfamily member 14 (LIGHT), CAR-T cells targeting prostate-specific membrane antigen (PSMA) can induce a variety of LTβR-related chemokines and adhesion molecules, remodeling the vasculature and lymphatic structures within the tumor, thereby enhancing the infiltration of DCs, NK cells, and T cells [99]. This evidence concerns the gene TNFSF14 and neoplasm.