In addition to the above synergistic mechanisms, McFadden and colleagues discovered that when CAR-T cells are used to deliver myxoma virus (MYXV), the IFNγ-protein kinase B (AKT) signaling pathway generated by T cells works in concert with the MYXV-induced M-T5-SKP-1-VPS34 signaling pathway to cause autophagy in tumor cells [153]. Here, AKT1 is linked to neoplasm.