This observation contrasts with other pediatric brain tumors such as glioblastomas, medulloblastomas, and choroid plexus carcinomas, where germline TP53 variants are more frequently seen.49–51 Our findings are however consistent with previous studies reporting an absence of germline TP53 variants in DMGs,11,13,52 noting isolated reports of germline TP53 variants in DMG.14,53. The gene discussed is TP53; the disease is glioblastoma.