ACVR1, a commonly altered gene in H3.1 mutant DMG16 was identified in the tumor of only 1 patient (H3.1 K27M) with a germline PALB2 deleterious variant compared to 27/186 (14.5%) patients who had somatic ACVR1 pathogenic variants detected in the non-germline mutant group, although this was not statistically significant (P = .70). This evidence concerns the gene ACVR1 and neoplasm.