Herein, we reported the results of an analysis conducted on 321 patients (retrospective dataset) and 75 patients (prospective dataset) affected by COVID‐19, in which the lung damage was evaluated and correlated to blood parameters such as lactates, pO2, pCO2, Hb, ferritin, and LDH at the hospital admission. This evidence concerns the gene GSTM1 and COVID-19.