Extrafollicular T/B cell responses have been associated with the induction of un‐/low‐mutated IgE with low affinity and no allergic or even anti‐allergic potential, whereas germinal center (GC)‐dependent B cell responses leading to highly mutated IgE with high affinity have been linked to the induction of allergic disease [29, 30, 31] (Figure 2). Here, IGHE is linked to allergic disease.