IGHE and Allergy: Yet paradoxically, (1) a proportion of healthy individuals possess allergen‐specific IgE without clinical signs of allergy; (2) some, but not all, allergic individuals develop a more severe disease over time or fail to respond to allergen‐specific immunotherapy; and (3) allergen‐specific IgG antibodies can inhibit IgE‐mediated responses but they can also induce allergic reactions.