To explore the potential of mPFC PV neurons as therapeutic targets in the anti-NMDAR encephalitis animal model, we injected photogenetic [AAV2/9-hSyn-DIO-hChR2(H134R)-mCherry or AAV2/9-hSyn-DIO-mCherry] or chemogenetic [AAV2/9-hSyn-DIO-hM3D(Gq)-mCherry or AAV2/9-hSyn-DIO-mCherry] viruses into the mPFC of PV-Cre mice and continued antibody injections to observe the effects of selective activation of PV neurons on cognitive behaviour (Fig. 4A and F). This evidence concerns the gene RIC8B and viral encephalitis.