RIC8B and encephalitis: To explore the potential of mPFC PV neurons as therapeutic targets in the anti-NMDAR encephalitis animal model, we injected photogenetic [AAV2/9-hSyn-DIO-hChR2(H134R)-mCherry or AAV2/9-hSyn-DIO-mCherry] or chemogenetic [AAV2/9-hSyn-DIO-hM3D(Gq)-mCherry or AAV2/9-hSyn-DIO-mCherry] viruses into the mPFC of PV-Cre mice and continued antibody injections to observe the effects of selective activation of PV neurons on cognitive behaviour (Fig. 4A and F).